Environmental Epigenetics

Research Themes

Research in the Pilsner Lab lies at the intersection of environmental toxicology, epidemiology, and reproductive health.  Our research has a particular emphasis on epigenetic mechanisms, which are additional layers of information intertwined with the genome that control the expression of genes. Specifically, our research focuses on taking a paternal perspective to reproductive health- to understand the role of sperm epigenetics as a biological pathway linking paternal environmental exposures to reproductive and offspring health. Research is conducted in two main domains: human population studies and complementary animal model experiments.  The centerpiece of our research in humans is the population-based study, Sperm Environmental Epigenetics and Development Study (SEEDS), in collaboration with Baystate Reproductive Medicine’s IVF clinic in Springfield, MA.  To complement our human research, we are also investigating the role of paternal environmental exposures on sperm epigenetics in rodent model systems.  

If you are a talented graduate or postdoctoral fellow interested in joining the Pilsner lab, click here.